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GHB or Gamma Hydroxybutyrate (C4H8O3) is a central nervous system (CNS) depressant that is commonly referred to as a “club drug” or “date rape” drug. GHB is abused by teens and young adults at bars, parties, clubs and “raves” (all night dance parties), and is often placed in alcoholic beverages. Euphoria, increased sex drive, and tranquility are reported positive effects of GHB abuse.1,2 Negative effects may include sweating, loss of consciousness (reported by 69 percent of users), nausea, hallucinations, amnesia, and coma, among other adverse effects.
Today, GHB is predominantly known in its illegal guise as a recreational drug taken by clubbers. Dosage in this scenario is much higher than naturally occurring levels of GHB - normally between 500mg and 3,000mg, compared with the 4.1-21.4mg found in an average litre of red wine.
Recreational users report feeling euphoric and generally exhibit increased sociability - much like the common party drug Ecstasy (MDMA). Anecdotal reports also link the GHB to an improved sexual desire and performance.
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γ-Hydroxybutyric acid, also known as 4-hydroxybutanoic acid, is a naturally occurring
neurotransmitter and a psychoactive drug. Wikipedia
Formula: C4H8O3
Classification: Hydroxybutyrates
Onset of action: Within 5-15 min
Metabolism: 95%, mainly liver, also in blood and tissues
Biological half-life: 30-60 minutes
IUPAC ID: 4-Hydroxybutanoic acid, Sodium 4-hydroxybutanoate
Soluble in: Alcohol, Water, Ether

What are GHB and GBL?

GHB (gammahydroxybutrate) and GBL (gammabutyrolactone), are closely related,
dangerous drugs with similar sedative and anaesthetic effects.

GBL is converted to GHB shortly after entering the body. Both produce a feeling of
euphoria and can reduce inhibitions and cause sleepiness.

GHB is also a naturally-occurring metabolite of the inhibitory neurotransmitter gamma-
aminobutyric acid (GABA) found in the brain. The naturally-occurring metabolite GHB is
present in much lower concentrations in the brain than those levels found when the drug is
abused. As a result of fermentation, natural GHB may also be found in small but
insignificant quantities in some beers and wines.

Pharmacology
GHB acts at two receptor sites in the brain, the GABAB and specific GHB receptors.
Action at these two receptor sites leads to the CNS depressant, stimulant and
psychomotor impairment effects of GHB. Roughly 95 percent of GHB is metabolized in
the liver, and it’s half-life ranges from 30 to 60 minutes. Only five percent of the parent
drug is excreted via the kidneys. Detection of GHB in the urine may be difficult after 24
hours due to it’s short half-life.

How does it affect the body?
Hallucinations
Euphoria, drowsiness, decreased anxiety, excited and aggressive behavior
Overdose symptoms: unconsciousness, seizures, slowed heart rate, greatly slowed
breathing, lower body temperature, vomiting, nausea, coma, death
Addictive. Withdrawal symptoms: insomnia, anxiety, tremors, increased heart rate and
blood pressure, psychotic thoughts.

What are its overdose effects?

GHB overdose can cause death.

Which drugs cause similar effects?
GHB analogues are often abused in place of GHB. Both GBL
and BD metabolize to GHB when taken and produce effects
similar to GHB.
CNS depressants such as barbiturates and methaqualone also
produce effects similar to GHB
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